NEJM：三岁看老！根据近4万人长远超35年的随访数据分析发现，孩童时期这五个危险因素与成年后患CVD相关丨临床大发现

不过，这项统计数据分析仍有许多不足之处。比如，由于i3C统计数据分析是于1970-1987年其间展开，当时人们对CVD的认识亦然不全面，只是测了总果糖，却残了低密度脂蛋白果糖（LDL-C）这个不可或缺的肠胃致命诱因；孩童的饮食生活习惯、营养摄入等诱因也从未确立统计数据分析。

希望未来有统计数据分析能够非常直白地得知我们，在具体哪个儿童或孩童后期，各个并不相同的肠胃致命诱因与年长CVD染病危险性间的就其持续性。

参考文献：

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[5]Hartiala O, Magnussen CG, Kajander S, et al. Adolescence risk factors are predictive of coronary artery calcification at middle age: the cardiovascular risk in young Finns study. J Am Coll Cardiol 2012;60:1364-1370.

[9]Sinaiko AR, Jacobs DR Jr, Woo JG, et al. The International Childhood Cardiovascular Cohort (i3C) Consortium outcomes study of childhood cardiovascular risk factors and adult cardiovascular morbidity and mortality: design and recruitment. Contemp Clin Trials 2018;69:55-64.

本文作者 | 张丹尼